ZFIN is now using GRCz12tu for Genomic Data

Gene

zeb2a

ID

ZDB-GENE-070912-553

Name

zinc finger E-box binding homeobox 2a

Symbol

zeb2a Nomenclature History

Previous Names

zeb2
sb:eu412
si:dkey-52o2.2
sip1a (1)
Smad-interacting protein-1a (1)
wu:fc92g08

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including head; nervous system; neural plate; neuroectoderm; and tail bud. Human ortholog(s) of this gene implicated in Hirschsprung's disease and Mowat-Wilson syndrome. Orthologous to human ZEB2 (zinc finger E-box binding homeobox 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu412 (26 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With zeb2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Mowat-Wilson syndrome	Alliance	Mowat-Wilson syndrome	235730

Associated With zeb2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR008598	Di19, zinc-binding domain
Domain	IPR013087	Zinc finger C2H2-type
Family	IPR051574	Zinc finger E-box-binding homeobox
Homologous_superfamily	IPR036236	Zinc finger C2H2 superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:B5DE38	InterPro	1175
UniProtKB:F1QY45	InterPro	1218
UniProtKB:A0A8M9Q4G0	InterPro	1095
UniProtKB:B0LVE9	InterPro	1201
UniProtKB:A0A8M2BFJ5	InterPro	1192
UniProtKB:A0AC58GCP6	InterPro	1242
UniProtKB:A0AC58GCP7	InterPro	1242
UniProtKB:A0AC58GCP8	InterPro	1242
UniProtKB:A0AC58GCP9	InterPro	1192
UniProtKB:A0AC58GCQ2	InterPro	1216
UniProtKB:A0AC58GCQ3	InterPro	1218
UniProtKB:A0AC58GCQ6	InterPro	1242
UniProtKB:A0AC58GCQ7	InterPro	1218
UniProtKB:A0AC58GCR0	InterPro	1192
UniProtKB:A0AC58GCR2	InterPro	1192
UniProtKB:A0AC58GCR3	InterPro	1095
UniProtKB:A0AC58GCR5	InterPro	1192
UniProtKB:A0AC58GCR7	InterPro	1216
UniProtKB:A0AC58GCR8	InterPro	1216
UniProtKB:A0AC58GCR9	InterPro	1069
UniProtKB:A0AC58GCS0	InterPro	1192
UniProtKB:A0AC58GCS3	InterPro	1218
UniProtKB:A0AC58GCS6	InterPro	1216
UniProtKB:A0AC58GCT1	InterPro	1218

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	zeb2a-201 (1) Ensembl	Ensembl	4,058 nt	Select Tool ZFIN BLAST
mRNA	zeb2a-202 (1) Ensembl	Ensembl	1,351 nt	Select Tool ZFIN BLAST
mRNA	zeb2a-203 (1) Ensembl	Ensembl	448 nt	Select Tool ZFIN BLAST
mRNA	zeb2a-204 (1) Ensembl	Ensembl	859 nt	Select Tool ZFIN BLAST
mRNA	zeb2a-206 (1) Ensembl	Ensembl	4,250 nt	Select Tool ZFIN BLAST
mRNA	zeb2a-207 (1) Ensembl	Ensembl	3,606 nt	Select Tool ZFIN BLAST
mRNA	zeb2a-208 (1) Ensembl	Ensembl	5,237 nt	Select Tool ZFIN BLAST
ncRNA	zeb2a-004 (1) Ensembl	Ensembl	940 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations